Talmi-Teshub was a local king and viceroy at Carchemish in Syria, during the reign of his overlord Great King Suppiluliuma II of Hatti.
He belonged to a local dynasty which was a branch of the Hittite royal family descending from Suppiluliuma I. He was the son of Ini-Teshub and great-great-great-grandson of Suppiluliuma I.
At Carchemish, Talmi-Teshub (r. 12xx-11xx BC) had the status as a regional king and viceroy to his overlord, the Great King of Hatti. He was preceded by Ini-Teshub and succeeded by Kuzu-Teshub. We know very little from his reign during which time the Hittite Empire was struggling.
As part of the Hittite Empire, Carchemish was the regional center in the eastern part of the empire bordering the frontier against Assyria.
According to royal seal impressions found at Lidar Höyük found in 1985 on the east bank of the Euphrates river, Talmi-Teshub was succeeded by his own son, Kuzi-Teshub.