Taguasco () is a municipality and town in the Sancti SpÃÂritus Province of Cuba.
It is located north-east of Sancti Spiritus, the provincial capital, and is bisected by Carretera Central highway between Cabaiguán and Jatibonico.
In 2022, the municipality of Taguasco had a population of 32,968. With a total area of , it has a population density of .