TYW5

TRNA-YW Synthesizing Protein 5 (TYW5) is a human protein that is encoded by the TYW5 gene.

Gene

TYW5 is located on chromosome 2q33.1 on the minus strand and spans 26,579 nucleotides.

Gene neighborhood

TYW5 is neighbored upstream by the genes C2orf69 (199,911,293 - 199,955,935) and Matrix AAA Peptidase Interacting Protein 1 (MAIP1) (199,955,317-200,008,540).

Protein

The TYW5 protein consists of 315 amino acids with a molecular mass of approximately 36.5 kDa. TYW5 functions as a homodimer and relies on Fe²⁺ ions as cofactors for its enzymatic activity, specifically involved in tRNA modification.

Evolution

Paralogs

There are four known paralogs to TYW5.

• HSPB1 Associated Protein 1 (HSPBAP1)
• Jumonji C Domain-Containing Protein 5 (JMJD5)
• Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor (HIF1AN)
• Jumonji Domain-Containing Protein 7 (JMJD7)

Orthologs

TYW5 in Homo sapiens is shown to be highly conserved. It is found in many vertebrates and invertebrates, as displayed in the table 1.

References