HC TSV Bayer 04 Leverkusen is a Germany professional women's handball club from Leverkusen representing TSV Bayer 04 Leverkusen in the Handball-Bundesliga Frauen.
Bayer Leverkusen won six national championships between 1965 and 1980, and six more titles in a row between 1982 and 1987, its most successful period. It was the only team from West Germany to reach the European Cup's final before the country's reunification, in 1984, and seven years later it also played the EHF Women's Cup's final. In 2005 it finally won its first international title, a Challenge Cup. In recent years it has won the 2010 German Cup and reached the EHF Cup and Cup Winners' Cup's semifinals. The club has the record for most DHB-Pokals won with 9 titles, the latest being in 2010.