TP-003 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.
TP-003 is a positive allosteric modulator at the benzodiazepine binding site of GABA<sub>A</sub> receptors. It possesses relative selectivity for benzodiazepine sites on ñ3-containing GABA<sub>A</sub> receptors, which are thought to contribute to the anxiolytic effects of benzodiazepines (in tandem with those containing ñ2 subunits). It has modest anticonvulsant activity although less than that of diazepam.