THCP-O-acetate (THCP-O) is a semi-synthetic derivative of tetrahydrocannabiphorol (THCP) derived by the O-acetylation of THCP with acetic anhydride. It has been found as a component of grey-market cannabis products and is allegedly a potent and long-lasting psychoactive cannabinoid.
In 2022, researchers at Portland State University reported that Vitamin E acetate, CBD-acetate, CBN-acetate and THC-O-acetate may break down to release ketene gas when heated at .
Japan banned THCP-O-Acetate along with HHCP on December 26, 2023.