Transcription factor II F (TF<sub>II</sub>F) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.
TF<sub>II</sub>F is encoded by the , , and genes.
TF<sub>II</sub>F binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TF<sub>II</sub>F stabilizes the RNA polymerase II while it's contacting TBP and TF<sub>II</sub>B.