TCS 1205 is a GABA<sub>A</sub> receptor positive allosteric modulator of the tryptamine family. It is a benzodiazepine site agonist selective for certain subunits.
TCS 1205 acts at the benzodiazepine binding site, it is selective for the ñ1 and ñ2 subunits of the GABA<sub>A</sub> receptor. In vivo, it has anxiolytic effects but no sedative effects.
Despite acting at the benzodiazepine receptor, it does not contain the benzodiazepine structure, it could therefore be classed as a nonbenzodiazepine. The drug is a substituted tryptamine derivative.