TC-1827 is an orally active, selective agonist of the ñ<sub>4</sub>ò<sub>2</sub> nicotinic receptors. Administration of TC-1827 improved memory and learning in a variety of rodents and increased long-term potentiation in hippocampal slices. In addition, the compound was without significant cardiovascular side effects, except for a small, transient rise in arterial blood pressure. The pro-cognitive effects of TC-1827 last much longer than the short half-life (0.2âÂÂ1.0 hours) would suggest.