Syntomodrillia lissotropis is a species of sea snail, a marine gastropod mollusk in the family Drilliidae.
The length of the shell attains 4.5 mm, its diameter 1.75 mm.
Original description, under the name P. (Mangilia) lissotropis, otherwise Mangilia lissotropis:
This marine species occurs in the Caribbean Sea and off Southern Brazil.