Streptomyces kunmingensis is a bacterium species from the genus of Streptomyces which has been isolated from soil from the Dagyanlow's Lake in Kunming in China.
The species is spore-forming, mesophilic (prefers moderate temperature), and develops an aerial mycelium â typical of manyâ¯Streptomyces. The type strain ofâ¯S. kunmingensisâ¯(DSM 41681) is maintained in major microbial culture collections and can be obtained for research. Culture data indicate standard cultivation media and incubation at around 28 ðC. A recent whole-genome sequencing project of a strain, S. kunmingensis TFRC-KFRI-1 assembled its genome into 12 contigs with a total size of about 4.76 megabases (Mb). The GC content was reported at 62.8%. The genome annotation identified 4,519 genes, including 4,451 protein-coding sequences (CDSs), along with rRNA and tRNA genes. Comparative analysis confirmed high sequence similarity (average nucleotide identity ~ 96.9%) to the type strain ofâ¯S. Kunmingensis. A strain ofâ¯S. kunmingensisâ¯produces a yellow-red extracellular pigment belonging to the chromopeptide class that has demonstrated potent antimicrobial activity againstâ¯Methicillin-Resistant Staphylococcus aureusâ¯(MRSA) andâ¯Mycobacterium tuberculosis. The molecule also showed antiproliferative effects on various human cancer cell lines and had wound-healing efficacy in rat models. Recent work has used a strain namedâ¯S. kunmingensisâ¯as a synbiotic supplement in feed for striped catfish (Pangasianodon hypophthalmus). Results after 3 months showed improved growth performance, enhanced nonspecific immunity (increased WBC, phagocytic activity), boosted lysozyme and complement activity, and significantly reduced mortality upon challenge with a pathogenic bacterium (Edwardsiella ictaluri). This suggestsâ¯S. kunmingensis â¯may be useful in sustainable aquaculture to enhance disease resistance.