Stauffer Run is a long 2nd order tributary to Jacobs Creek in Westmoreland County, Pennsylvania.
Stauffer Run rises about 0.5 miles southwest of West Bethany, Pennsylvania, and then flows south to join Jacobs Creek at Scottdale.
Stauffer Run drains of area, receives about 42.1 in/year of precipitation, has a wetness index of 377.03, and is about 27% forested.