St Mark's Church, Derby is a parish church in the Church of England in Chaddesden, Derbyshire.
In 1897 a small corrugated iron church was erected at the junction of Francis Street and St Mark's Road, Derby.
The foundation stone for the permanent church was laid on 5 January 1935 by Edith Haslam of Breadsall Priory. The contractor for the construction was J.K. Ford and Weston of Osmaston Road, Derby. The cost was ã11,000 (). It was opened on 18 December 1935.
The church is ambulatory. There is a series of eight parabolic arches united by reinforced concrete beams at ground level, ambulatory level and roof level, these form the skeleton of the building.
The church is in a joint parish with St Philip's Church, Chaddesden.
The church has a pipe organ by Kingsgate Davidson dating from 1935. A specification of the organ can be found on the National Pipe Organ Register.