St. Stephen's Episcopal Pro-Cathedral is an Episcopal church located in Wilkes-Barre, Luzerne County, Pennsylvania. It was the Pro-Cathedral in the former Diocese of Bethlehem. The Cathedral Church of the Nativity in Bethlehem, Pennsylvania served as the primary cathedral of the former diocese.
St. Stephen's Church began in 1817. The present church building is the fifth one for the parish. It was completed in 1897 and consecrated in 1899. Philadelphia architect Charles M. Burns designed the church in the Romanesque Revival style.
In 2024, the cathedral reported average Sunday attendance (ASA) of 44 persons and plate and pledge income of $557,140; in 2023, it reported 271 members.