St. Luke AME Zion Church is a historic African Methodist Episcopal Zion (AMEZ) church at 3937 12th Ave. North in Birmingham, Alabama. The congregation was established in 1888 and the current building was constructed in 1930. It was significant in the civil rights movement., in part because it, along with two neighboring churches which no longer stand were bombed on January 16, 1962. It was added to the National Register of Historic Places in 2005.