St. Luke's Episcopal Church is a historic Episcopal church at Cannelton, Indiana. Built about 1845–1846, it is a rectangular Greek Revival style frame building with a gable roof. It was lengthened by 17 feet in 1864, and features a three-story centered bell tower on the front facade.
The church reported 19 members in 2023; no membership statistics were reported in 2024 parochial reports. Plate and pledge income reported for the congregation in 2024 was $4,368. Average Sunday attendance (ASA) in 2024 was 0 persons.
It was listed on the National Register of Historic Places in 1983. It is located in the Cannelton Historic District.