St. Louis and San Francisco Railroad Building, also known as the Frisco Building, is a historic train station and office building located at Joplin, Jasper County, Missouri. It was built in 1913 for the St. Louis and San Francisco Railroad, and is a nine-story, L-shaped, brick-and-stone-trimmed building with a decorative cornice. It measures approximately 101 feet by 127 feet and has a two-part vertical block form.
It was listed on the National Register of Historic Places in 2002. It is located in the Joplin Downtown Historic District.