St. Francisville or Saint Francisville is an unincorporated community and census-designated place in northeast Clark County, Missouri, United States. As of the 2020 census, its population was 137.
The community is on Missouri Route B four miles north of Wayland. The Des Moines River and the Missouri-Iowa border are one-half mile north of the community. It is the oldest settlement in Clark County, Missouri.
St. Francisville was platted in 1833, by a man named Francis Church.
It is in the Clark County R-I School District. The district's comprehensive high school is Clark County High School.