St. Charles High School may refer to one of several schools in the United States:
- St. Charles East High School, public school in St. Charles, Illinois
- St. Charles North High School, public school in St. Charles, Illinois
- St. Charles High School, Waldorf school in Charles County Public Schools system, Maryland
- St. Charles High School (Minnesota), public school in St. Charles, Minnesota
- St. Charles High School (Missouri), public school in St. Charles, Missouri
- St. Charles West High School, public school in St. Charles, Missouri
- Saint Charles Preparatory School, Catholic private school in Columbus, Ohio
See also