St. Charles or Saint Charles is an unincorporated community and census-designated place (CDP) in Lee County, South Carolina, United States. It was first listed as a CDP prior to the 2020 census with a population of 114.
The CDP is in southern Lee County, at the junction of U.S. Route 401 and South Carolina Highway 154. Highway 401 leads northeast to Darlington and southwest to Sumter, while Highway 154 leads north to Bishopville and south to Mayesville.
Note: the US Census treats Hispanic/Latino as an ethnic category. This table excludes Latinos from the racial categories and assigns them to a separate category. Hispanics/Latinos can be of any race.