Spring Creek is a stream in Maries and Phelps counties of Missouri. It is a tributary of Gasconade River.
The stream headwaters arise in Phelps County just northeast of Rolla near the Missouri Route V interchange on I-44 (at ) and stream flows to the north-northwest passing under Missouri Route 63 about three miles north of Rolla. The stream enters Maries County near its midpoint, crosses under Missouri Route A and flows parallel to and just south of Route 63 again to its confluence with the Gasconade (at ) about four miles southeast of Vienna.
Spring Creek was named for the fact there are abundant springs along its course.