Spencer Burford (born July 19, 2000) is an American professional football guard for the Las Vegas Raiders of the National Football League (NFL). He played college football for the UTSA Roadrunners. He was selected by the San Francisco 49ers in the fourth round of the 2022 NFL draft.
Burford was selected by the San Francisco 49ers in the fourth round, 134th overall, of the 2022 NFL draft. As a rookie, he appeared in and started 16 games.
On September 20, 2025, Burford was placed on injured reserve due to a knee injury suffered in Week 2 against the New Orleans Saints. On November 1, Burford was activated from injured reserve ahead of the team's Week 9 game against the New York Giants.
On March 17, 2026, the Las Vegas Raiders signed Burford to a one-year, $3.25 million contract with $1.24 million guaranteed and a signing bonus of $1.5 million.