The Southern Hotel in Llano, Texas was constructed circa 1881 by stonemasons J. K. Finlay and John Goodman in the Second Empire style for owner J.W. Owen. Originally built as a stagecoach stop between Mason and Burnet, it later served as both a hotel and a boarding house. Initially a two-story building, a third floor was added when Colonel W.A.H. Miller bought the hotel in 1883. It was later renamed the Colonial Inn and ceased operations in the 1950s.
The hotel was designated a Recorded Texas Historic Landmark in 1980 (Marker number 9455) and was added to the National Register of Historic Places in Texas on October 10, 1979.