The Southern Cone Mesopotamian savanna, also known as the Argentine Mesopotamian grasslands, is a flooded grassland ecoregion of Argentina and southern Paraguay.
The ecoregion covers an area of , lying west of the Uruguay River in Argentina's Corrientes Province, extending north into the adjacent portion of Misiones Province.
The ecoregion is covered by a mosaic of seasonally wet habitats, including grasslands, marshes, woodland, and gallery forests.
The Mesopotamian savanna is an endemic bird area, with three endemic species, two of which are threatened.