South Moreau Creek is a stream in Miller and Cole Counties of Missouri, United States. It is a tributary of the Moreau River, part of the Mississippi Basin.
The headwaters are at northwest of Miller County at . The stream flows to the northeastern direction, crossing into the southern portion of Moniteau County. South Moreau Creek has an average elevation of above the sea level. It and the North Moreau Creek form a confluence at , where both creeks enter the Moreau River.