South Fork is an unincorporated community and census-designated place (CDP) in Howell County, Missouri, United States. It is located southwest of West Plains on U.S. Route 160. As of the 2020 census, South Fork had a population of 212.
A post office called South Fork was established in 1860, and remained in operation until 1960. The community was named after the nearby South Fork of the Spring River.