South Esk Pine Reserve is a nature reserve in eastern Tasmania, Australia, north-east of Hobart, on the Apsley River near Coles Bay. It is owned and managed by Bush Heritage Australia (BHA), by which it was purchased in 1998.
The reserve protects the last large stand of the Tasmanian endemic conifer South Esk Pine. This tree is considered vulnerable, with only 10,000 trees remaining.