South Cascade Glacier is a large alpine glacier in the North Cascades of Washington, USA. It is bordered on the east by Sentinel Peak, and is about north of Glacier Peak in the Glacier Peak Wilderness. Meltwater from the glacier flows directly into South Cascade Lake, which feeds the South Fork Cascade River, which is a tributary of the Skagit River.
South Cascade Glacier is one of the four "benchmark glaciers" that is monitored by the USGS and its mass balance has been monitored since 1959. Its area has declined from 2.71 km<sup>2</sup> in 1958 to 1.8 km<sup>2</sup> in 2015 representing an area loss of 34%. Between 1958 and 2009 South Cascade Glacier lost nearly a half of its volume.