South Carolina Highway 652 (SC 652) is a state highway in the U.S. state of South Carolina. The highway travels through rural areas of Jasper County. It is known as Calf Pen Bay Road for its entire length.
SC 652 begins at an intersection with U.S. Route 601 (US 601; Cypress Branch Road) in Pineland. It travels to the east-northeast and curves to the southeast until it meets its eastern terminus, an intersection with US 278 (Grays Highway) at a point north-northwest of Ridgeland.