South Carolina Highway 50 (SC 50) was a state highway that existed in the central part of Orangeburg County. It connected Cordova and Orangeburg.
SC 50 began at an intersection with U.S. Route 21 (US 21) and SC 5 (now Oakland Avenue) in Rock Hill. It traveled to the east on Cedar Street, crossed over a railroad line, and traveled on Curtis Street to end at Mill Street.
SC 50 was established by 1943. It was decommissioned in 1947. It was downgraded to secondary roads.