The South Africa cricket team toured England in September 2025 to play the England cricket team. The tour consisted of three One Day International (ODI) and three Twenty20 International (T20I) matches. In August 2024, the England and Wales Cricket Board (ECB) confirmed the fixtures for the tour, as a part of the 2025 home international season.
On 1 September, Codi Yusuf was added to the ODI squad. On 3 September, Tony de Zorzi was ruled out of the remainder of the ODI series due to a hamstring injury. On 9 September, David Miller was ruled out of the T20I series due to a hamstring injury. On 10 September, Lungi Ngidi was ruled out of the T20I series due to a hamstring injury, and was replaced by Nandre Burger. On the same day Keshav Maharaj was ruled out of the T20I series due to a groin injury, and was replaced by Bjorn Fortuin.
On 5 September, Ben Duckett was rested from the T20I series. He was replaced by Sam Curran.