The Sousa River (, ) is a river in Portugal, a tributary of the Douro. It rises in the parish of Friande, Felgueiras, in the Porto District of northwest Portugal, and is a right tributary of the Douro, which it meets at the parish of Foz do Sousa, Gondomar, about 16 km from the mouth of the Douro.
The name is from Latin ' 'rocks', later called Sausa.