Somatostatin receptors are receptors for the ligand somatostatin, a small neuropeptide associated with neural signaling, particularly in the post-synaptic response to NMDA receptor co-stimulation/activation. Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB.
There are five known somatostatin receptors: SST1 and SST4 are potential targets for the treatment of Alzheimer's disease.
All are G protein-coupled seven transmembrane receptors.