Sofignano is an Italian village and frazione belonging to the municipality of Vaiano, in the Province of Prato, Tuscany.
The village is located 2 km from Vaiano, on the mid side of the western face of the Calvana Hill.
Sofignano also includes the hamlets of Boana, Ca' dei Landi, Casanera, Collisassi, Colombaia, Docciola, Fattoria delle Mura, L'Olmo, La Lastruccia, Il Baldino, and Le Fornaci.