SirReal2 is a drug which acts as a potent and selective sirtuin 2 (SIRT2) inhibitor. It inhibits SIRT2 with an IC<sub>50</sub> of 140nM, and is selective over SIRT1, SIRT3 and SIRT5. It is used in research into cancer, inflammation and neurodegenerative disorders such as Parkinson's disease, and has led to the discovery of a number of related derivatives.