Sione Maile Tupou (born 25 May 1994) is a Tongan international rugby union player.
A back-row forward, Tupou captains Tonga in rugby sevens. He led the team at the 2022 Rugby World Cup Sevens and 2022 Commonwealth Games, where he was a flag bear for Tonga in the Parade of Nations.
Tupou made his debut for the Tonga XV in a 2023 Test against Canada in Nukuûalofa.