The Simpson Memorial United Methodist Church is a historic United Methodist church located at Greenville, Indiana. It was designed by church plan catalogue architect Benjamin D. Price and built by Capt. John Nafius in 1899. It is a frame Gothic Revival style church built on the Akron Plan and topped by a hipped and gable roof. It features lancet windows and a corner bell tower topped with four square piers sheathed in tin.
It was listed on the National Register of Historic Places in 2004.