Signe Holt Andersen (born 28 August 1999) is a Danish footballer who plays as a forward for Danish Women's League club AGF Fodbold.
Since 2016, Andersen has featured for various Elitedivisionen clubs Växjö DFF, VSK Aarhus, and after the transfer in summer of 2024, AGF Fodbold. She also previously played for Lazio in Italy.
She has represented Denmark from under-16 to under-23 youth level.