The Signakh uezd was a county (uezd) of the Tiflis Governorate of the Caucasus Viceroyalty of the Russian Empire, and then of Democratic Republic of Georgia, with its administrative centre in Signakh (present-day Signagi). The area of the county corresponded to part of the contemporary Kakheti region of Georgia.
Following the Russian Revolution, the Signakh uezd was incorporated into the short-lived Democratic Republic of Georgia.
The subcounties (uchastoks) of the Signakh uezd in 1913 were as follows:
According to the 1897 Russian Empire census, the Signakh uezd had a population of 102,313 on , including 55,958 men and 46,355 women. The majority of the population indicated Georgian to be their mother tongue, with significant Armenian and Tatar speaking minorities.
According to the 1917 publication of Kavkazskiy kalendar, the Signakh uezd had a population of 153,864 on , including 80,670 men and 73,194 women, 148,646 of whom were the permanent population, and 5,218 were temporary residents: