Sibley and Holmwood Candy Factory and Witkop and Holmes Headquarters, also known as the Weed & Company Building, are two connected historic commercial buildings located in downtown Buffalo, Erie County, New York, United States. The Sibley & Holmwood Candy Factory (149 Swan Street) was built in 1896 and is a five-story, nine-bay-wide brick commercial block with late-Gothic detailing. It features Gothic window arches, decorative cast-iron columns on the storefront, and corbelled cornice. The Witkop & Holmes Headquarters (145 Swan Street) was designed by the architectural firm Bethune, Bethune & Fuchs and built in 1901. It is a four-story, three-bay-wide brick commercial block. Both buildings have flat roofs. The building has been renovated to house loft apartments.
It was listed on the National Register of Historic Places in 2014.