Shirley Run is a long 3rd order tributary to Thompson Creek in Crawford County, Pennsylvania.
Shirley Run rises about 2 miles northeast of Vrooman, Pennsylvania, in Blue Swamp at the Warren County line and then flows south-southwest to join Thompson Creek at Shelmandine Springs.
Shirley Run drains of area, receives about 45.6 in/year of precipitation, has a wetness index of 450.87, and is about 52% forested.