Shireen Amir Begum was the first wife and cousin of Zulfikar Ali Bhutto, who served as the fourth president and ninth prime minister of Pakistan. She was the daughter of Khan Bahadur Ahmad Khan Bhutto, the brother of Sir Shah Nawaz Bhutto. She was married to Zulfikar Ali Bhutto in 1943, at the time she was ten years his senior. The couple had no children.
She died from a cardiac arrest on 19 January 2003 and was laid to rest in the Bhutto family mausoleum.