Shesh Khaneh () is a village in Eshqabad Rural District of the Central District in Maneh County, North Khorasan province, Iran.
At the time of the 2006 National Census, the village's population was 185 in 38 households, when it was in Atrak Rural District of Maneh District in Maneh and Samalqan County. The following census in 2011 counted 149 people in 42 households. The 2016 census measured the population of the village as 183 people in 58 households.
In 2023, the district was separated from the county in the establishment of Maneh County and renamed the Central District. Shesh Khaneh was transferred to Eshqabad Rural District created in the same district.