The Sherdar Madrasa (from ; ) is a 17th-century madrasa (Islamic school) located on the Registan in the historic center of Samarkand, a UNESCO World Heritage Site in Uzbekistan. The madrasa's name references the distinctive tiger-lion mosaics on its façade.
The Sherdar Madrasa was built by Yalangtush Bahadur, an Uzbek ruler and governor of Samarkand under the Ashtarkhanid (Janid) dynasty in the 17th century. The madrasa was constructed between 1619 and 1636.
Together with the Ulugh Beg and Tilakari madrasas, it forms the monumental ensemble of the Registan, the ancient heart of the city. The building is considered one of the main tourist attractions in Samarkand and is known for its profuse tile decoration and polychrome plant-themed paintings.