Sheppard Run is a long first-order tributary to East Branch Tunungwant Creek.
According to the Geographic Names Information System, it has also been known historically as:
Sheppard Run rises about west of Howard, Pennsylvania, and then flows northeast to meet East Branch Tunungwant Creek at Custer City, Pennsylvania.
Sheppard Run drains of area, receives about of precipitation, and is about 90.47% forested.