Sheepskin Run is a long 1st order tributary to the Youghiogheny River in Fayette County, Pennsylvania.
Sheepskin Run rises about 1 mile northeast of Ohiopyle, Pennsylvania, and then flows southwest to join the Youghiogheny River about 0.25 miles east of Ohiopyle.
Sheepskin Run drains of area, receives about 47.3 in/year of precipitation, has a wetness index of 332.00, and is about 94% forested.