Shahrixon District () is a tuman (district) of Andijan Region in Uzbekistan. The capital lies at the city Shahrixon. It has an area of and it had 310,000 inhabitants in 2022.
The district consists of 1 city (Shahrixon), 3 urban-type settlements (Vaxim, Choûja and Segazaqum) and 12 rural communities (incl. Nazarmaxram).
The kishlak of Nazarmaxram, located in the district, was the district center of Xoldevonbek District, abolished in 1962.