Seyfert Mill is a historic grist mill located in Upper Tulpehocken Township, Berks County, Pennsylvania. The combined mill and house building was built in 1840, and is a 2 1/2-story, with basement, banked stone building. It measures . Also on the property are the contributing millrace and pond. The mill ceased operation in about 1954.
It was listed on the National Register of Historic Places in 1990.