Sextus Pomponius () was a Roman jurist who lived during the reigns of Hadrian, Antoninus Pius, and Marcus Aurelius.
Sextus was a fairly common Roman given name () while his surname seems to indicate he belonged to the Pomponia family (). Other writers have expressed a view that the name Sextus Pomponius was shared by another jurist, although Puchta suggested the assumption of two Pomponii was unsupported by the evidence.
S. Pomponius wrote a book on the law up to the time of Hadrian, known as the Enchiridion (, EnkheidÃÂrion, "Handbook"). A long excerpt of the work forms part of Justinian's Digest dealing with the origin of the Roman Constitution and various offices.