<span class="plainlinks"></span>
Setiptiline (brand name Tecipul), also known as teciptiline, is a tetracyclic antidepressant (TeCA) that acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It was launched in 1989 for the treatment of depression in Japan by Mochida.
Setiptiline acts as a norepinephrine reuptake inhibitor, ñ<sub>2</sub>-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT<sub>2</sub> subtypes, as well as an H<sub>1</sub> receptor inverse agonist/antihistamine.
Setiptiline has a tetracyclic structure and is a close analogue of mianserin and mirtazapine, with setiptiline being delta(13b,4a),4a-carba-mianserin, and mirtazapine being 6-azamianserin.